Continuously updated synthesis method about C4H4N2O

The chemical industry reduces the impact on the environment during synthesis Imidazole-2-carboxaldehyde. I believe this compound will play a more active role in future production and life.

Application of 10111-08-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10111-08-7, name is Imidazole-2-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

Part A Preparation 2-hydroxymethyl-1H-imidazole 2-Imidazolecarboxyaldehyde (5.0 g, 52.0 mmol) was suspended in 200 mL of methanol. NaBH4 (3.95 g, 0.10 mol) was added portion-wise. The reaction mixture was stirred at room temperature for 1 h under N2. It was quenched with 10 mL of brine. The solvent was removed. The solid was washed with 5% MeOH in CH2Cl2. The inorganic solid was filtered off. The filtrate was concentrated and chromatographed with 5% MeOH in CH2Cl2 to give 2.32 g off-white solid (45.2% yield). 1H NMR (DMSO-d6): delta 6.86 (s, 2H), 4.40 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis Imidazole-2-carboxaldehyde. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Quan, Mimi L.; US2003/144287; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem