Application of 288-32-4, These common heterocyclic compound, 288-32-4, name is 1H-Imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Three-necked flask,In the presence of nitrogen,31.8 g (300 mmol) of sodium carbonate,28.2 g (100 mmol) of 1- (1-trifluoromethanesulfonate) ethyl-2,3-dimethylbenzene,[1,1′-bis (diphenylphosphino) ferrocene] palladium dichloride 3.5 g (5 mmol),Imidazole (8.2 g, 120 mmol) and 52 ml of [BuPy] BF4,The reaction was stirred at 70 C for 30 minutes,After monitoring the reaction,Pour into the water,Dichloromethane extraction,The organic phase was washed three times,Dry the organic phase over anhydrous sodium sulfate,Concentrated under reduced pressure,The petroleum ether was recrystallized to obtain 17.6 g of 4- [1- (2,3-dimethylphenyl) ethyl] -1H-imidazole,Yield 84.7%(S) -4- [1- (2,3-dimethylphenyl) ethyl] -1H-imidazoleee value of 79.89%.
The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tsingtao Chenda Biological Technology Co., Ltd.; Lv Yanhua; (6 pag.)CN106588779; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem