Related Products of 7757-21-3, These common heterocyclic compound, 7757-21-3, name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a single neck flask equipped with a condenser and under nitrogen atmosphere was charged 2-CHLORO-3-NITROPYRIDINE (25g, 0. 158 MOLE), Aminomethylbenzimidazole hydrochloride (36. 5g, 0.166 mole) and 200 ml of Ethanol. To this slurry was charged diisopropylethyl amine (137 ml, 0.790 mole) and heated to 65 degrees celcius for 1 hour. Tlc in 5% methanol/ Methylene Chloride (product Rf; 0.5). The reaction was concentrated under vacuo to 100 ml and then cool in an ice bath. Filtered solid and washed cake with minimal amount of Methyl ethyl Ketone to give (LH-BENZOIMIDAZOL-2-YLMETHYL)- (3-NITRO-PYRIDIN-2-YL)-AMINE, a canary Yellow solid (wt= 15.76 g)
Statistics shows that (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride is playing an increasingly important role. we look forward to future research findings about 7757-21-3.
Reference:
Patent; TRIMERIS, INC.; WO2004/43913; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem