Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C13H15ClN2O
(1) 5 kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole, fully dissolved in 35 kg of methylene chloride,5kg of thionyl chloride was added dropwise at a rate of 1.5ml/s at 20C, and the temperature was slowly raised to 32C and the reaction was incubated for 1 hour.Then reflux at 60 C for 1 hour, slowly cooled to 15 C to obtain the reaction solution;(2) In the reaction solution obtained in step (1), add 10C water at a rate of 0.5 ml/s while stirring.The volume ratio of liquid to water is 0.005:1, and then anhydrous sodium carbonate is added at 1.3 kg/L, suction filtration,The solid was discarded, and the liquid was concentrated at 55 C until no dichloromethane was distilled off.Dry, that is, too. Upon detection, the yield of the product of this example was 99.18%.The target product and impurity levels were determined using HPLC and standards. After testing,The target product, 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole, has a content of 99.17%.
According to the analysis of related databases, 67085-11-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Li Fujun; Bai Lu; Peng Kaifeng; Wen Fengqiu; Li Sanxin; Gong Yun; (10 pag.)CN105198814; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem