Synthetic Route of 45676-04-8, A common heterocyclic compound, 45676-04-8, name is 1-tert-Butylimidazole, molecular formula is C7H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.2.7) 3-tert-Butyl-1-[(tert-butyl(methyl)phosphinooxy)methyl]imidazolium tosylate 15 In a Schlenk tube with pressure release valve, 1.00 g (3.3 mmol) of tert-butyl(methyl)-(tosylmethyl)phosphine oxide (14) and 0.45 g (3.6 mmol) of N-tert-butylimidazole (1) were stirred in 0.7 ml of toluene at 105 C. for 72 hours. The red-brown, viscous oil was precipitated from 10 ml of hexane in an ultrasound bath.
The synthetic route of 45676-04-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; US2010/317866; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem