Reference of 16681-59-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16681-59-7 as follows.
2-Bromo-l -methyl- 1H- imidazole (47 mu-, 0.48 mmol) was dissolved in diethyl ether (2 mL) and cooled to -75C under argon. Butyl lithium (2.5 M in hexanes: 192 (uL, 0.48 mmol) was added dropwise and the mixture stirred at -75C for 1 hour. A solution of (R)-l-(4- fluorophenyl)-6-((4-(trifluoromemyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-lH-pyra.zolo[3,4- g]isoqumoline~4a~carbaldehyde (252 mg, 0.5 mmol) in diethyl ether (2 mL) was added dropwise The reaction mixture was stirred for 16 hours whilst warming slowly to room temperature. The reaction mixture was cooled and treated with water (10 mL) and the phases separated. The organic phase was extracted with further diethyl ether (x2) followed by diehloromethane (x2). The combined organic phases were dried over sodium sulfate, the solids were removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (gradient: 17.5 to 25% acetone in cyelohexane) to afford (R)-(l-(4-fluorophenyl)-6-((4-(Mflu^ pyrazolo[3,4-g]isQquinoim-4a-yi)(l as a white powder (82 mg) LCMS (Method A, ESI): RT 2.74 min, m+H = 588.1
According to the analysis of related databases, 16681-59-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CORCEPT THERAPEUTICS, INC.; HUNT, Hazel; JOHNSON, Tony; RAY, Nicholas; WALTERS, Iain; WO2013/177559; (2013); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem