Adding a certain compound to certain chemical reactions, such as: 2301-25-9, name is 1-(4-Nitrophenyl)-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2301-25-9, name: 1-(4-Nitrophenyl)-1H-imidazole
Part B. Preparation of 1-(3-cyanophenyl)-3-methyl-5-[(4′-(N-imidazolyl)phenyl)aminocarbonyl]pyrazole The product from part A was then coupled to 1-(3-cyanophenyl)-3-methylpyrazole-5-carboxylic acid via the acid chloride methodology described previously to afford the desired amide which was then purified via standard reverse phase HPLC techniques to afford the desired material. 1 H-NMR (DMSO-d6, 300 MHz) delta: 10.73 (s,1H) 9.35 (bs,1H) 8.13 (s,1H) 7.95 (s,1H) 7.90-7.60 (complex,8H) 7.0 (s,1H) 2.30 (s,3H) ppm; ESI mass spectrum analysis m/z (rel. intensity) 369 (m+H, 100); HRMS calc. mass 369.146384; found 369.145884.
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Reference:
Patent; DuPont Pharmaceuticals Company; US6020357; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem