Application of 641571-11-1,Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Take 250ml three mouth flask,The raw amine 3 (1.00 g, 4.15 mmol) was placed,20 ml of water was added,The temperature of the reaction system was lowered to 0 C,0.23 g of HCl was diluted in 5 ml of water and added dropwise to the reaction system,With the addition of HCl,The viscosity of the reaction system is increasing,So we carry out this step reaction is best to use mechanical stirring,After completion of the dropwise addition, stirring was continued at 0 C for 1 hour,Further, 20 ml of an aqueous solution of 0.28 g of sodium nitrite was added to the reaction system,Stirring was continued for 0.5 h.The above reaction solution system was added to KI (0.83 g) at 0 C,CuI (0.97 g) in 20 ml of water,Plus completed,The whole reaction system was gradually heated to 75 C,The reaction system has a bubble,Nitrogen gas is generated,When bubbles are no longer generated,To the reaction system, 50 ml of ethyl acetate was added to extract the product,The reaction process yield is not high,The reason for this is that the diazonium salts produced by Compound 3 are unstable,With the increase of temperature,Some of the diazonium salts have not decomposed before the iodide ion has been replaced.Too pure silica gel column,Compound 4 was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, its application will become more common.
Reference:
Patent; Tianjin International Joint Academy of Biomedicine; Rao, Zihe; Yang, Cheng; Chen, Yue; Bai, Cuigai; Sun, Tao; Pan, Chengwen; Meng, Fanfei; Li, Yongtao; Wang, Jinghan; Jiang, Yin; (41 pag.)CN106188005; (2016); A;,
Imidazole – Wikipedia,
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