Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2034-22-2, name is 2,4,5-Tribromoimidazole, A new synthetic method of this compound is introduced below., Formula: C3HBr3N2
dimethyl sulfoxide (300 mL) suspension of (2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane (10.9 g), 2,4,5-tribromo-1H-imidazole (14.3 g) and cesium carbonate (18.4 g) was stirred for 4 hours at 130C . The reaction mixture was allowed to cool to room temperature, after the addition of water and ethyl acetate, the organic layer was separated and the water layer. The aqueous layer was extracted twice with ethyl acetate, combined organic layer, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography (Reveleris, mobile phase: hexane / ethyl acetate = 90/10 ~ 50/50; v / v) to give the title compound (Intermediate 1: 4.73 g, pale yellow oil) was obtained .
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TAISHO PHARMACEUTICAL CO LTD; URABE, HIROKI; NISHIKAWA, RIE; TAMIDA, TOMOKO; HATTORI, NOBUTAKA; SAKAGAMI, KAZUNARI; MATSUDA, YOHEI; YASUHARA, AKITO; (67 pag.)JP2015/6994; (2015); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem