In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 288-32-4 as follows. name: 1H-Imidazole
General procedure: General Procedure for Ultrasound-Promoted Iodination of Aromaticand Heteroaromatic Compounds: Hydrogen peroxide 30% (m/v) (4-8 mmol) was added to a suspension of theappropriate aromatic or heteroaromatic compound (1a-q) (2 mmol) and moleculariodine (2-4 mmol) in distilled water (10 mL). The mixture was sonicated and the progressof reaction was monitored by thin-layer chromatography (TLC). Afterward, asaturated sodium thiosulfate aqueous solution (10 mL) was added to the mixture,which was extracted with ethyl acetate (320mL). The organic phase was dried overMgSO4. After filtration, the solvent was evaporated under reduced pressure. The residuewas purified by column chromatography on silica gel using an appropriate eluent,affording the desired product (2a-q).
According to the analysis of related databases, 288-32-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ferreira, Irlon M.; Casagrande, Gleison A.; Pizzuti, Lucas; Raminelli, Cristiano; Synthetic Communications; vol. 44; 14; (2014); p. 2094 – 2102;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem