Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Computed Properties of C5H6N2O
lb lb. 3-({4-[(2-Hydroxyethyl)(methyl)carbamoyl]phenyl}({l-[(4-methyl-lH-imidazol-5-yl)methyl]piperidin-4-ylidene})methyl)benzamide 3-({4-[(2-Hydroxyethyl)(methyl)carbam benzamide (79.0 mg, 0.2 mmol) was dissolved in 1 ,2-dichloroethane (2 mL) and acetic acid (57 muIota_, 1 .0 mmol) was added followed by 5-methylimidazole-4-carboxaldehyde (44.0 mg, 0.4 mmol) and NaBH(OAc)3 (169 mg, 0.8 mmol). The reaction was stirred at 50C for 48 h. The crude was purified by flash chromatography (ethyl acetate, ethyl acetate/methanol 75:25) to give the title compound as a crude material. This material was then purified by preparative HPLC (X-bridge column, 50 mM NH4HCO3 as mobile phase, CH3CN from 10 to 40) to give 5 mg of the title compound. MS m/z 488 [M+H]+.
The synthetic route of 68282-53-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMNOVO AB; VON MENTZER, Bengt; STARKE, Ingemar; BRANDT, Peter; (24 pag.)WO2016/99394; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem