Synthetic Route of 152628-02-9,Some common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of an appropriate benzimidazole (5.03mmol) and NaH (0.12g, 5.53mmol, 60%) in 100mL anhydrous THF was stirred for 30minat 50C. After cooling to rt, a mixture of an appropriate bromide (6.04mmol) in anhydrous THF (50mL) was added dropwise to the solution. The solution was stirred for 3hat 50C. Then the resulting mixture was poured into 30mL ice water, and extracted with ethyl acetate (50mL×3). The combined organic layer was dried over MgSO4. After filtration, the solvent was removed under reduced pressure and the residue was purified by CC to give the product as white solid 4.1.7.8 [5-[[2-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone (15c) 15c was prepared by following the above general procedure. Yield: 85.6%. MP: 214-217 C. 1H NMR (400 MHz, CDCl3): delta 8.35 (d, 1H), 7.86 (s, 1H), 7.78 (d, 2H), 7.60 (t, 2H), 7.54 (t, 2H), 7.43 (s, 2H), 7.34 (d, 2H), 7.31 (t, 2H), 7.28 (d, 1H), 6.73 (d, 1H), 5.68 (s, 2H), 3.74 (s, 3H), 2.94 (t, 2H), 2.78 (s, 3H), 1.85 (m, 2H), 1.04 (t, 3H). MS (ESI): [M + H]+ calcd 538.3; found 538.3.
The synthetic route of 152628-02-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhu, Weibo; Bao, Xiaolu; Ren, He; Da, Yajing; Wu, Dan; Li, Fuming; Yan, Yijia; Wang, Li; Chen, Zhilong; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 161 – 178;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem