Reference of 870837-18-6,Some common heterocyclic compound, 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, molecular formula is C12H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of t-BuOK (1 M in THF, 0.80ml) was added dropwise to a stirred mixture of B6 (R7 = p-SF5-Phenyl and R6 = carboethoxyl, 0.41 g) and A1(157 mg, R10 = 3-MeO-Phenyl, R9 = 4-(4-Methyl-imidazol-1 -yl) and R8 = H) in 10 ml_ of anhydrous THF at -70eC under nitrogen atmosphere. The reaction mixture was stirred between -709C and -30QC until starting material were consumed. The reaction was quenched with iced brine, and extracted with EtOAc. The organic phase was washed with aqueous NH4CI and brine, dried over anhydrous magnesium sulfate, filtered and solvent evaporated. The residue was purified by a flash silica gel column and eluted with DCM/MeOH to give 0.38g B7 (R7 = p-SF5-Phenyl, R6 = carboethoxyl, R10 = 3-MeO-Phenyl, R9 = 4-(4-Methyl-imidazol- 1-yl)).
The synthetic route of 870837-18-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; XU, Ruo; CLADER, John, W.; WO2010/54064; (2010); A1;,
Imidazole – Wikipedia,
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