Application of 16042-25-4, These common heterocyclic compound, 16042-25-4, name is 2-Imidazolecarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00535] lH-Imidazole-2-carboxylic acid { 3-r4-(6-cyclohexylamino-9H-purin-2-ylamino)-3-methylphenoxylpropyl|amide (C14): Diisopropylethyl amine (0.10 g, 0.81 mmol) was added to a solution of lH-imidazole-2-carboxylic acid (0.025 g, 0.22 mmol), N- 2-[4-(3-aminopropoxy)-2-methyl-phenyl]-N-6-cyclohexyl-9H-purine-2,6-diamine (0.08 g, 0.20 mmol), EDCI (0.046 g, 0.24 mmol), and HOBt (0.037 g, 0.24 mmol) in DMF (1.0 mL), and the resulting mixture was stirred overnight at ambient temperature. The solvent was removed and the crude material was purified by reverse-phase HPLC to provide compound (Table 1, C14).
The synthetic route of 16042-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MYRIAD PHARMACEUTICALS, INC.; KUMAR, Dange, Vijay; MCALEXANDER, Ian, A.; BURSAVICH, Matthew, Gregory; HOARAU, Christophe; SLATTUM, Paul, M.; GERRISH, David, A.; LOCKMAN, Jeffrey, W.; JUDD, Weston, R.; SAUNDERS, Michael; PARKER, Daniel, P.; ZIGAR, Daniel, Feodore; KIM, In, Chul; WILLARDSEN, J., Adam; YAGER, Kraig, M.; SHENDEROVICH, Mark, D.; WILLIAMS, Brandi, L.; TARDIF, Keith, D.; WO2010/111406; (2010); A2;,
Imidazole – Wikipedia,
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