In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10040-98-9 as follows. category: imidazoles-derivatives
General procedure: A methanolic sodium hydroxide solution (10%; 10.0 mL) was added drop-wise to a mixture of 1-(4-(1H-imidazol-1-yl)phenyl)ethanone(3) (10.0 mmol, 1.86 g), aromatic aldehyde (10.0 mmol) and methanol (50 mL) over a period of 30-40 min with continuous stirring at room temperature until completion of the reaction (as indicated by TLC). The reaction flask was kept in the freezer overnight. The obtained precipitates were filtered off and washed with a cold methanol-water mixture (1:10). Finally the product was purified by column chromatography using CHCl3:MeOH (97:3) as a solvent.
According to the analysis of related databases, 10040-98-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Hussain, Tanvir; Zia-Ur-Rehman, Muhammad; Zaheer, Muhammad; Ashraf, Chouhdary Muhammad; Bolte, Michael; Journal of Chemical Research; vol. 40; 4; (2016); p. 199 – 204;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem