Reference of 14741-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of compound 3 (2.04 g, 0.01 mol) in ethanol (40 mL) containing triethylamine (0.50 mL) phenylisothiocyanate (1.30 g, 0.01 mol) was added. The reaction mixture was heated under reflux for 4 h then poured onto ice/water mixture containing few drops of hydrochloric acid and the formed solid product was collected by filtration. Yellow crystals from ethanol; yield: 2.67 g (87%); m.p. 202 oC. IR, : 3057 (CH aromatic), 2980 (CH2), 1689 (CO), 1643 (C=N), 1632 (C=C).1H-NMR: : 5.90 (s, 2H, pyrimidine CH2), 7.26-7.38 (m, 9H, C6H4, C6H5). 13C NMR (DMSO): 54.2 (CH2), 120.3, 123.7, 124.1, 124.6, 124.9, 125.8, 129.3, 126.7, 127.2, 128.2 (C6H5, C6H4), 163.4 (CO), 173.6 (C=N), 180.3 (C=S); Anal. calcd for C16H11N3OS: C, 65.51; H, 3.78; N, 14.32; S, 10.93%. Found: C, 65.33; H, 4.02; N, 14.59; S, 11.27%. MS: m/z: (%) 293 (M+, 22%).
The synthetic route of Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem