51-17-2, name is 1H-Benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 51-17-2
N-Methylimidazole, quinoline, benzimidazole, iodomethaneand anhydrous NiBr2 were purchased from Sigma-Aldrich (>99%)and used as received. N-Methyl-benzimidazole was synthesizedaccording to a known literature method [10]: Benzimidazole (25.0 g, 211.6 mmol) is added in one portion to 100 mL of a stirred ice-cold 50% aqueous NaOH solution. Iodomethane (33.0 g, 232.8 mmol) is added dropwise under vigorous stirring to the clear benzimidazole solution at ambient temperature. After 1 h the solution is extracted three times with 100 mL portions of chloroform. The combined organic phases are dried with Na2SO4 and the solvent is removed under reduced pressure. The residue is distilled in vacuo, yielding N-methyl-benzimidazole as a colorless liquid, which solidifies upon cooling. Yield: 21.0 g (75%), mp. 61 C. Elemental anal. % (calc. for C8H8N2): C, 72.50 (72.70); H, 6.19 (6.10); N, 21.18 (21.20).
The synthetic route of 51-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Peppel, Tim; Hinz, Alexander; Koeckerling, Martin; Polyhedron; vol. 52; (2013); p. 482 – 490;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem