Application of 35203-44-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35203-44-2 name is 1-Propyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(Reference Example 19) Synthesis of 1-propyl-1H-imidazole-2-carbaldehyde: A solution of 1-propyl-1H-imidazole (1.67 g, 15.2 mmol) in tetrahydrofuran (30.4 mL) was cooled to -78°C. n-Butyllithium (1.62 M n-hexane solution, 10.3 mL, 16.7 mmol) was added to the reaction liquid at -78°C. The reaction liquid was stirred at the same temperature for 1 hour and then N,N-dimethylformamide (1.41 mL, 18.2 mmol) was added at -78°C. After the reaction liquid was stirred at the same temperature for 1 hour, the temperature of the reaction liquid was raised to room temperature. A saturated aqueous solution of ammonium chloride was added to the reaction liquid and then ethyl acetate was added. The organic layer was washed with a 10percent aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, n-hexane/ethyl acetate) to obtain 1-propyl-1H-imidazole-2-carbaldehyde (0.492 g, 3.56 mmol, 24percent) as a colorless oil. 1H-NMR (400 MHz, CDCl3) delta: 0.91-0.95 (3H, m), 1.79-1.84 (2H, m), 4.34-4.38 (2H, m), 7.15 (1H, s), 7.28 (1H, s), 9.82 (1H, s). ESI-MS: m/z= 139 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Propyl-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Patent; Toray Industries, Inc.; ARAI Tadamasa; MORITA Yasuhiro; UDAGAWA Shuji; ISEKI Katsuhiko; IZUMIMOTO Naoki; (95 pag.)EP3263565; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem