In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 930-62-1 as follows. Application In Synthesis of 2,4-Dimethylimidazole
(3) taking 20 mmol of 2,4-dimethylimidazole in 10 mL of DMSO,Add 40 mmol of ground NaOH,After heating to 60 C, 20 mmol of chloromethylbenzotriazole was added, heated in a water bath at 60 C for 60 min, cooled to room temperature, poured into 50 g of ice water, and a precipitate was formed by stirring, and suction filtration was performed.The precipitate was washed 3 times with water.Obtain a crude product;(4) The crude product was recrystallized by adding ethyl acetate at 78 C to obtain yellow-white crystals, which was the ligand 1-(benzotriazole-1-methyl)-1-(2,4-dimethyl Imidazole).
According to the analysis of related databases, 930-62-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Henan University of Traditional Chinese Medicine; Wang Xia; Ling Ning; Yang Jing; Zeng Dai; Cheng Di; Zhang Yawen; Yang Huaixia; (12 pag.)CN108774252; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem