Related Products of 38993-84-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38993-84-9 name is (1-Methyl-1H-imidazol-5-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of triphosgene (62 mg, 0.21 mmol) in DCM (4.0 mL) was added to a stirred solution of A13 (prepared as described in: WO 2013/055987; 500 mg, 0.525 mmol) and Et3N (120 mg, 1.18 mmol) in DCM (16 mL) at 20 °C. The resulting mixture was stirred at that temperature for 2 h. A solution of (1-methyl-1H-imidazol-5-yl)methanol (80 mg, 0.709 mmol) in DCM (3 mL) was then added followed by nBu2Sn(OAc)2 (2 drops). The reaction mixture was stirred at 20 °C for 16 h under N2 then was concentrated under reduced pressure. The residue was purified by prep-TLC (DCM/MeOH=30/1) to give A17 as a yellow solid (250 mg, yield: 44percent). LCMS (condition A): RT = 0.97 min, m/z = 1091.6 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1-Methyl-1H-imidazol-5-yl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Dragovich, Peter S.; Broccatelli, Fabio; Chen, Jinhua; Fan, Peter; Le, Hoa; Mao, Weiguang; Pillow, Thomas H.; Polson, Andrew G.; Wai, John; Xu, Zijin; Yao, Hui; Zhang, Donglu; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5300 – 5304;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem