Adding a certain compound to certain chemical reactions, such as: 1467-16-9, name is 1H-Imidazole hydrochloride, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1467-16-9, name: 1H-Imidazole hydrochloride
A mixture of lithium(1+) ion 3-amino-5H-pyrrolo[2,3-£>]pyrazine-2-carboxylate, Intermediate 3 (5.00 g, 27.2 mmol), CDI (6.61 g, 40.7 mmol) and 1 /-/-imidazole hydrochloride (1 :1) (3.12 g, 29.9 mmol) in DMF (80 ml) was stirred at RT for 16 h. Additional CDI (2.00 g, 12.3 mmol) was added and the reaction was left to stir for a further 1 h at RT. The reaction mixture was diluted with water (350 ml) then stirred at RT for 5 min then left to stand at RT for 0.5 h. The resultant mixture was filtered then the collected solid was washed with water then dried under vacuum to afford the product as a yellow/orange solid (3.30 g, 52%). 1 H NMR (500 MHz, DMSO-cfe) delta 11.69 (s, 1 H), 8.74 (t, J = 0.9 Hz, 1 H), 7.94 (t, J = 1.4 Hz, 1 H), 7.63 (dd, J = 3.8, 2.3 Hz, 1 H), 7.44 (s, 2H), 7.08 (dd, J = 1.5, 0.8 Hz, 1 H), 6.52 (dd, J = 3.8, 1.3 Hz, 1 H). LC/MS (System A): m/z (ESI+) = 229 [MH+], Rt = 0.65 min, UV purity = 97%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; MCCARTHY, Clive; HARGRAVE, Jonathan, David; HAY, Duncan, Alexander; SCHOFIELD, Thomas, Beauregard; WENT, Naomi; (261 pag.)WO2018/96325; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem