Reference of 6160-65-2, These common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3-[4-(-mercapto-5-methoxy-benzimidazole-1-sulfonyl)- [PHENOXY]-2,] 2-dimethyl-propionic acid methyl ester (Intermediate A39,16. 1 g, 0.0395 mol) in pyridine (200 mL) was added 1,1′-thiocarbonyldiimidazole (10.56 g, 0.0592 mol). The reaction mixture was stirred at room temperature overnight and then water was added (2.5 L). After stirring for 1 hr, the solid was collected, washed with water (3 L), and dried to give 16.5 g (93%) of the title compound, benzimidazolethiol as a tan solid.
Statistics shows that 1,1′-Thiocarbonyldiimidazole is playing an increasingly important role. we look forward to future research findings about 6160-65-2.
Reference:
Patent; GARST, Michael, E.; SACHS, George; SHIN, Jai, Moo; WO2004/9583; (2004); A2;,
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