Some common heterocyclic compound, 57531-37-0, name is 2-Chloro-5-nitroimidazole, molecular formula is C3H2ClN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 57531-37-0
A solution of 2,4 ‘ -dibromoacetophenone (5 g, 18 mmol), 2-chloro-4-nitro- lH-imidazole (4 g, 27 mmol, 1.5 equiv.) and K2CO3 (3.73 g, 27 mmol, 1.5 equiv) in CH3CN (180 mL) was stirred at 60 0C for 2h. The reaction mixture was cooled to rt, and the solids precipitates were filtered. The precipitates were washed with water and the filtered mixture of organic solvents and water were separated. The organic layers were concentrated and recrystalized with acetone to provide 5.5 g (15.99 mmol, 89percent) of brown solid. ESI MS m/z 346 (M + H+) with bromine doublet pattern.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57531-37-0, its application will become more common.
Reference:
Patent; GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT; WO2009/120789; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem