Some common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate
Example 17: Synthesis of Compound 5A [0300] To a suspension of SMI (4.32 g, 25.0 mmol) and SM2 (5.0 g, 25.0 mmol) in ethanol (100 mL) was added SM3 (4.9 g, 50.0mmol) and the mixture was stirred at room temperature for 20 min. The reaction mixture was heated to reflux for 6 h. The mixture was then cooled to 20 C and the precipitate collected by filtration, washed with EtOH, Et20 and dried to give compound 5A (5.0 g, yield=50%, Lot: MC13021-014-03) as a pale yellow solid. LCMS: m/z 390 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 14741-71-0, its application will become more common.
Reference:
Patent; HADDACH, Mustapha; WO2015/172123; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem