Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 312-73-2
General procedure: A flame-dried round-bottomed flask was charged with 3-bromoisocoumarine (0.13 mmol) azole (1.2 eq), Pd2(dba)3 (5mol %), Xantphos (10 mol %) and K2CO3 (2.0 eq) in dry toluene (1.0 mL). The mixture was heated under nitrogen atmosphere at 80 C for 12h. After completion of the reaction as indicated by TLC, the mixture was cooled to room temperature and solvent removed under reduced pressure. The crude residue was purified by flash column chromatography on silica gel to afford the corresponding product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Simic, Milena; Paunovic, Nikola; Boric, Ivan; Randjelovic, Jelena; Vojnovic, Sandra; Nikodinovic-Runic, Jasmina; Pekmezovic, Marina; Savic, Vladimir; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 235 – 239;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem