Adding a certain compound to certain chemical reactions, such as: 401567-00-8, name is 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 401567-00-8, Recommanded Product: 401567-00-8
General procedure: A mixture of 10 (345 mg, 0.853 mmol), 2,5-dichlorobenzimidazole (11a) (191 mg, 1.02 mmol) and N,N-diisopropylethylamine (0.18 mL, 1.0 mmol) in N-methyl-2-pyrrolidone (6 mL) was stirred at 100 C overnight. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with brine, dried and concentrated under reduced pressure. The residue was purified by high performance liquid chromatography to give 3-{(2S,4S)-1-benzyloxycarbonyl-4-[4-(5-chlorobenzimidazol-2-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine (122 mg, 26%) as a pale-yellow powder.A mixture of the above compound (110 mg, 0.198 mmol) and 30% hydrogen bromide-acetic acid solution (10 mL) was stirred at room temperature for 6 h. Diethyl ether was added to the reaction mixture, and the precipitate was collected by filtration and recrystallized with ethanol to give the title compound (56 mg, 40%) as a white powder.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Article; Yoshida, Tomohiro; Akahoshi, Fumihiko; Sakashita, Hiroshi; Sonda, Shuji; Takeuchi, Masahiro; Tanaka, Yoshihito; Nabeno, Mika; Kishida, Hiroyuki; Miyaguchi, Ikuko; Hayashi, Yoshiharu; Bioorganic and Medicinal Chemistry; vol. 20; 16; (2012); p. 5033 – 5041;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem