Some common heterocyclic compound, 38993-84-9, name is (1-Methyl-1H-imidazol-5-yl)methanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 38993-84-9
A mixture of (1-methyl-1H-imidazol-5-yl) methanol (500MG, 4.5 mmol) in DMF (5 ML) at-5 oC was slowly treated with thionyl chloride (0.49 ML, 6.7 mmol), stirred an additional 10 minutes AT-5 C, warmed to room temperature, stirred 1.5 hours, cooled TO-5 C, quenched with isopropyl alcohol and ethyl acetate, stirred 30 minutes AT-5 C, concentrated under vacuum, and filtered to collect the solid. The solid was rinsed with ethyl acetate and dried under vacuum to give (212mg, 28percent) of the desired product as the hydrochloride salt. MS (DCI) m/e 131 (M+H) + ; 1H NMR (300 MHz, DMSO-D6) 8 9.10 (S, 1H), 7.76 (s, 1H), 5.02 (s, 2H), 3.88 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 38993-84-9, its application will become more common.
Reference:
Patent; ABBOTT LABORATORIES; WO2004/76424; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem