Synthetic Route of 20485-43-2, The chemical industry reduces the impact on the environment during synthesis 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, I believe this compound will play a more active role in future production and life.
HATU (O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate) (1.75g; 4.60 mmol) was added in on portion to a stirring solution of 1-methyl-1 H- imidazole-2-carboxylic acid (509 mg; 4.04 mmol), lambda/,O-dimethylhydroxylamine hydrochloride (391 mg; 4.01 mmol), and diisopropylethylamine (2.0 ml 1 1.9 mmol) in anhydrous DMF (14 ml_). The mixture was stirred at room temperature for 17 hours and partitioned between ethyl acetate (100 ml.) and water (100 ml_). The organic phase was dried (MgSO4) and concentrated in vacuo, giving a colourless oil (1.45 g). This was purified by column chromatography, giving the title compound as a colourless oil (494 mg; 73%). 1H-NMR (400MHz, CDCI3): 3.57 (3H, br s), 3.86 (3H, s), 3.91 (3H, s), 6.97 (1 H, d, J=I Hz), 7.07 (1 H, d, J=I Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2007/107539; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem