Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33543-78-1, name is Ethyl 1H-imidazole-2-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 33543-78-1
An ice-cold solution of ethylimidazole-2-carboxylate (5.1 g, 36.4 mmol) in conc sulfuric acid (15 mL,281 mmol) was treated dropwise with fuming HNO3 (15 mL). The mixture was heated at 60 °C for 2.5 hr, cooled and then poured onto ice (150 g). The resulting solid was collected by vacuum filtration, washed with water, and dried in vacuo to afford the title compound 12p as a colourless powder (4.2 g, 64percent). LCMS: Rt = 2.49 min, 99 Apercent 254 nm, [M – H]- = 184.0. 1H NMR (600 MHz,DMSO-d6) delta 8.55 (s, 1H), 4.38 (q, J = 7.1 Hz, 2H), 1.35 (t, J = 7.1 Hz, 3H). 13C NMR (150 MHz,DMSO-d6) delta 157.6, 147.4, 135.9, 122.1, 61.9, 14.0. The 1H data was consistent with previousreports [4].
The synthetic route of 33543-78-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jarrad; Debnath; Miyamoto; Hansford; Pelingon; Butler; Bains; Karoli; Blaskovich; Eckmann; Cooper; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 353 – 362;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem