These common heterocyclic compound, 2302-25-2, name is 4-Bromo-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H3BrN2
A mixture of 4-bromo-lH-imidazole (223 mg, 1.52 mmol), 4- fluorophenylboronic acid (425 mg, 3.03 mmol), copper (II) acetate (413 mg, 2. 28 mmol), pyridine (0.25 mL) and powdered 4A molecular sieves (1 g) in 1,2-dichloroethane (7mL) was stirred at room temperature under a slow stream of air for 44 hours. The reaction mixture was filtered through Celite (D, washing with ethyl acetate. The filtrate was concentrated and the residue purified by flash column chromatography on silica eluting with 10 to 20% ethyl acetate/isohexane to give the product as a white solid (135 mg, 37%). 8 (iH, 400MHz, CDCl8) 7.16-7. 22 (3H, m), 7.32-7. 37 (2H, m), 7.65 (1H, d, J = 1.5 Hz). MS (ES+) 241,243 ([MH]+).
The synthetic route of 4-Bromo-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2003/93252; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem