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Reference of 41806-40-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41806-40-0 name is 1-Methylimidazole-5-carboxylic Acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 72 (METHOD T); N-r4-(6,6-Dimethyl-4-oxo-4,5,6,7-tetrahvdrori.31thiazolor5.4-clpyridin-2-yl)-3,4- dihvdro-2H- 1 ,4-benzoxazin-6-yl]- 1 -methyl-lH-imidazole-5-carboxamide; To a stirred solution of Example 42 (0.025 g, 0.08 mmol) in DCM (1 mL) were added l-methylimidazol-5-ylcarboxylic acid (0.013 g, 0.10 mmol), DIPEA (0.02 mL, 0.10 mmol), EDC (0.030 g, 0.16 mmol) and HOBT (0.05 g, 0.04 mmol). The reaction mixture was stirred at r.t. for 18 h, then concentrated in vacuo. Purification by preparative HPLC (Method 6) gave the title compound (0.01 g, 29%) as a yellow oil. 6H (CDCl3) 9.25 (IH, s), 8.46-8.43 (IH, m), 7.33 (IH, dd, J8.9 and 2.4 Hz), 7.07 (IH, d, J 0.9 Hz), 7.02 (IH, d, J0.8 Hz), 6.94 (IH, d, J 8.9 Hz), 5.56 (IH, br. s), 4.36-4.29 (2H, m), 4.16-4.09 (2H, m), 4.11 (3H, s), 2.90 (2H, s), 1.40 (6H, s). LCMS (ES+) 439.4 (M+H)+, RT 2.69 minutes (Method 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methylimidazole-5-carboxylic Acid, and friends who are interested can also refer to it.

Reference:
Patent; UCB PHARMA S.A.; WO2008/1076; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem