20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1-Methyl-1H-imidazole-2-carboxylic acid
A mixture of 5-methyl-2- (2-pyridyl)-5 ,6,7 ,8-tetrahydropyrido [4,3 d]pyrimidine trifluoroacetic acid salt (100 mg, 442 imol, the product of step 2 in Example 34), 1- methylimidazole-2-carboxylic acid (83.6 mg, 663 j.imol), HATU (336 mg, 884 imol) and DIPEA (171 mg, 1.33 mmol) in DMF (5 mL) was stuffed overnight at rt. The resulting mixturewas poured into water and extracted with DCM (30 mL) twice. The combined organic layer was concentrated in vacuo and the residue was purified by prep-HPLC to give (1-methylimidazol-2- yl)- [5-methyl-2- (2-pyridyl)-7 ,8 -dihydro-5H-pyrido [4,3-d]pyrimidin-6-yl] methanone (69 mg) as a light yellow solid. ?H NMR (400 MHz, Methanol-d4) oe: 8.5 1-8.80 (m, 2H), 8.33-8.43 (m, 1H), 7.80-7.92 (m, 1H), 7.34-7.47 (m, 1H), 7.07-7.18 (m, 1H), 6.97 (d, 1H), 5.66-5.86 (m, 1H), 4.66-4.75 (m, 0.4H), 4.49-4.60 (m, 0.6H), 3.74 (s, 3H), 3.48-3.63 (m, 0.7H), 3.23-3.41 (m, 1H), 2.88-3.15 (m, 1.3H), 1.56 (brd, 3H). MS obsd. (ESI)[(M+H)]: 335.
The synthetic route of 20485-43-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Jianhua; WANG, Min; YANG, Song; (84 pag.)WO2018/83106; (2018); A1;,
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