Related Products of 1219741-19-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1219741-19-1 name is 5-Chloro-6-iodo-2-(methylsulfonyl)-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of potassium phosphate, tribasic (2 M solution in water; 21 mL, 42 mmol), Pd(PPh3)4 (0.324 g, 0.280 mmol), 4-biphenylboronic acid (3.94 g, 1 .9 mmol) and 6-chloro-5-iodo-2- (methylsulfonyl)-lH-benzimidazole (Intermediate 1, 5 g, 14 mmol) in dioxane (70 mL) was heated at 100C for 5 h. The aqueous phase was removed and the organic phase wasconcentrated, diluted with EtOAc and DCM, and filtered. The filtrate was concentrated to afford the desired product as a white solid, which was used in the next step without further purification
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-6-iodo-2-(methylsulfonyl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; JIANG, Jinlong; KASSICK, Andrew, J.; KEKEC, Ahmet; SEBHAT, Iyassu, K.; WO2011/106273; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem