The important role of

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78581-99-4, name is 5,6-Difluorobenzimidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 78581-99-4

27: Methyi 3-{[(1 /?)-1-(2-chioro-3-hydroxyphenvi)ethv?oxv}-5- (5.6-dif iuoro-1 MbenzimidazoS-1 -yl)-2-thiophenecarboxyiateStep A – Methyl 5-{5,6-dif.uoro-1 Mbe?zimidazoi-1-yl)~3-hydroxy~2- thiophe?ecarboxylate To a mixture of 5,6-dif.upsilonoro-1 Mbenzsmidazoie (0.5 g, 3.2 rnmol) and 2-chioro- 3-oxo-2,3~dihydro~2-thiophenecarboxyiate (0.72 g, 3.7 mrnof) in 10 mL of CHCI3 was added Mmefhyiimidazole (0.4 g, 4.9 mrnol) and NaHCO3 (0.82 g, 5 9.7 mmol). The mixture was heated to 550C for 24 h. Silica gel (2 g) was added and the voiatites were evaporated under reduced pressure and the residue was purified by flash column chromatography (0 to 50% EtOAc: DCIVI) to afford 0.71 g of the tilted compound, MS (ESI): 311 [M+H]*.

According to the analysis of related databases, 78581-99-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/143456; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem