Related Products of 615-16-7, These common heterocyclic compound, 615-16-7, name is 2-Hydroxybenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of compound 114 (1 g, 7.46 mmol) in CH2C12 (10 mL) under argon atmosphere was added chlorosulfonic acid (1 mL, 14.92 mmol) at 0 C; heated to reflux and stirred for 16 h. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo and the residue diluted with water (10 mL); neutralized with aqueous NaOH solution and extracted with EtOAc (3 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford compound 115 (980 mg, 58%) as an off-white solid. TLC: 10% MeOH/ CH2C12 (Rf. 0.5); 1H-NMR (DMSO-i/tf, 400 MHz): delta 10.66 (s, 1H), 10.61 (s, 1H), 7.24 (d, J= 6.4 Hz, 1H), 7.18 (s, 1H), 6.85 (d, J = 8.4 Hz, 1H).
The synthetic route of 615-16-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ARNOLD, Lee Daniel; MAAG, Hans; TURNER, JR., William W.; (274 pag.)WO2016/168619; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem