Adding a certain compound to certain chemical reactions, such as: 123470-47-3, name is 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123470-47-3, Safety of 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione
1-Formyl-4-(2-hydroxyethyl)piperazine (1.11 g, 7.0 mmol), 5,6-difluoro-2-mercaptobenzimidazole (1.30 g, 7.0 mmol), and diisopropylethylamine (3.62 g, 28.0 mmol) were dissolved in propionitrile (50 mL), and cyanomethyltrimethylphosphonium iodide (6.80 g, 28.0 mmol) was added thereto, followed by stirring for one hour at 92 C. under argon. The reaction mixture was allowed to cool and then poured in water (100 mL), followed by extraction with chloroform (100 mL*3). The organic layer was washed with saturated brine and then dried over sodium sulfate anhydrate, and the product was concentrated under reduced pressure. The crude product was crystallized from acetone-ether, to thereby yield 1-[2-(5,6-difluorobenzimidazol-2-ylthio)ethyl]-4-formylpiperazine (1.78 g, yield 78%) as a yellow crystalline powder. mp: 197.0-198.0 C. IR (KBr) cm-1: 3441, 2825, 1648, 1476, 1431, 1363. 1H-NMR (DMSO-d6): delta2.38 (2H, t, J=5.1 Hz), 2.44 (2H, t, J=5.0 Hz), 2.69 (2H, t, J=7.0 Hz), 3.23-3.38 (4H, m), 3.41 (2H, t, J=7.0 Hz), 7,38-7.58 (2H, m), 7.97 (1H, s), 12.8 (1H s). MS (m/z): 326 (M+), 140 (100).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kowa Co., Ltd.; US2005/20606; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem