Adding a certain compound to certain chemical reactions, such as: 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 96797-15-8, Quality Control of 4-Iodo-1-trityl-1H-imidazole
Ethyl magnesium bromide (IM) in tetrahydrofuran (12.66 mL, 12.66 mmol) was added to the solution of 4-iodo-l-trityl-lH-imidazole (4.6g, 10.55 mmol) in freshly distilled dry tetrahydrofuran (46.0 mL) at an ambient temperature and the reaction mixture was stirred for about 90 minutes. Zinc chloride (IM) (12.66 mL, 12.66 mmol) was added at an ambient temperature and was stirred for another about 90 minutes. The reaction mixture was degassed for about 20 minutes. Tetrakis(triphenylphosphine) palladium (0.61g, 0.527 mmol) and 5-bromo-2-chloro pyrimidine (2.24 g,l 1.6 mmol) was added and the reaction mixture was stirred for about 12-14 hours at about 700C. The reaction mixture was cooled and diluted with dichloromethane, washed with aqueous solution of EDTA (PH=9), brine, dried over anhydrous sodium sulphate, filtered and concentrated to form the solid, which was purified by column chromatography using ethyl acetate-hexane as eluents. Yield: 3.0g
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2007/60618; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem