Reference of 3034-38-6, These common heterocyclic compound, 3034-38-6, name is 5-Nitro-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Nitroimidazole 6 (5.6 g, 50 mmol) was dissolved in a minimumamount of concentrated sulfuric acid and a mixture of fumingnitric acid (20 mL) and concentrated sulfuric acid (25 mL) wasadded to it. The resulting solution was refluxed for 5 h and aftercooling poured onto crushed ice and the mixture was adjusted topH 2 with sodium bicarbonate. The product was extracted byethyl acetate (3 50 mL). Concentration the extract yielded 7 asyellow crystals (3.5 g, 22 mmol); mp: 171-173 C (lit. mp166-169 cC) [41].
Statistics shows that 5-Nitro-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 3034-38-6.
Reference:
Article; Shirvani, Pouria; Fassihi, Afshin; Saghaie, Lotfollah; Van Belle, Siska; Debyser, Zeger; Christ, Frauke; Journal of Molecular Structure; vol. 1202; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem