Electric Literature of 104619-51-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 104619-51-4 name is Di(1H-imidazol-1-yl)methanimine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
An oven dried round bottom flask was charged withdi(IH-imidazol-l-yl)methanimine (500 mg, 3.10 mmol),2-aminophenol (188 mg, 1.724 mmol) and anhydrous THF(20 ml) at room temperature. The resulting suspension wasrefluxed under N2 for 2 hr to give complete conversion basedon LC/MS. The solvent was removed in vacuo and the residuewas purified on a Biotage Flash Collector, eluting with30-80% EtOAc/Hexane (1200 ml) to afford the expectedproduct, benzo[d]oxazol-2-amine (200 mg, 1.5 mmol, 87%yield), as a white solid
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Di(1H-imidazol-1-yl)methanimine, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, JAMES H; MCDONALD, IVAR M; KING, DALTON; OLSON, RICHARD E; WANG, NENGHUI; IWUAGWU, CHRISTIANA I; ZUSI, F.CHRISTOPHER; MACOR, JOHN E; (330 pag.)JP5714745; (2015); B2;,
Imidazole – Wikipedia,
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