Reference of 4887-80-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4887-80-3 as follows.
5 g of methoxybenzimidazole (44.5 mg, 0.3 mmol), NaHCO3 (12.6 mg, 50 mol%), NFSI (142 mg, 1.5 equiv.) Were added to 2.0 mL of acetonitrile and the reaction was stopped for 12 h at 70 C , Column chromatography (silica gel column; eluent: petroleum ether / ethyl acetate = 25/2) to give 2 g of sulfonylated 5-methoxybenzimidazole. The product was a white solid in 67% yield
According to the analysis of related databases, 4887-80-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nanchang University; Guo Shengmei; Jie Kun; Cai Hu; (12 pag.)CN107501194; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem