Reference of 36947-68-9,Some common heterocyclic compound, 36947-68-9, name is 2-Isopropyl-1H-imidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 20; 4-(2-isoPropyl-1H-imidazol-1-yl)piperidine; Methanesulphonyl chloride (0.27 mL, 3.4 mmol) was added dropwise to a stirring mixture of 1-tertbutoxycarbonyl-4-hydroxypiperidine (457 mg, 2.27 mmol) and triethylamine (0.95mL, 6.8 mmol) in dichloromethane (10 mL) at 0 C. under nitrogen. After 20 mins, the mixture was allowed to warm to room temperature and stirred for a further 30 mins. Water (10 mL) was added and the organic layer was separated and the solvent evaporated under reduced pressure. The residue was taken up in acetonitrile (10 mL) and 2-isopropylimidazole (250 mg, 2.27 mmol) and cesium carbonate (880 mg, 22.7 mmol) were added. The mixture was refluxed for 3 days and then allowed to cool. The mixture was filtered and the solvent was removed in vacuo. The residue was filtered through a silica plug using ethyl acetate and the solvent was removed under reduced pressure. The residue was dissolved in methanol (5 mL) and ethereal hydrogen chloride (5 mL of a 2N solution) was added. The mixture was stirred overnight, the solvent was removed in vacuo and the residue was chromatographed on silica gel using an elution gradient of dichloromethane to 94:6:0.6 dichloromethane:methanol:0.88 ammonia as eluant to afford the title compound as a white solid, 28 mg.LRMS: m/z APCI 194 [MH]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Isopropyl-1H-imidazole, its application will become more common.
Reference:
Patent; PFIZER INC; US2009/209578; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem