Application of 1402838-08-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, This compound has unique chemical properties. The synthetic route is as follows.
The compound 5-e (540 mg, 1.30 mmol), compound 29-e (see Patent: WO2012142237)(400 mg, 1.37 mmol), potassium carbonate (360 mg, 2.60 mmol) and ethanol (20 mL) was refluxed for 1 hour. Will reverseThe mixture was concentrated under reduced pressure, dichloromethane (50 mL) was added, washed successively with water (20 mL x 3) and saturated brine (50 mL).The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized from petroleum ether and ethyl acetate to giveCompound 29-d (590 mg, 78%) as a white solid.
The chemical industry reduces the impact on the environment during synthesis 2-(1-Trityl-4-imidazolyl)benzaldehyde. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shanghai Yingli Pharmaceutical Co., Ltd.; Xu Zusheng; Lou Yangtong; Wu Tianzhi; (87 pag.)CN106478634; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem