In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1402838-08-7 as follows. Safety of 2-(1-Trityl-4-imidazolyl)benzaldehyde
Compound 0403-119 (397 mg, 1.39 mmol, 1.9 equiv),Compound 2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (300 mg, 0.72 mmol, 1 eq) andCesium carbonate (468 mg, 1.44 mmol, 2 eq)Mixed in isopropanol (10 ml),The mixture was stirred at room temperature for 16 hours.After the reaction was completed, quenched with water and filtered to give the target product 1-(benzodioxan-6-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)benzene. The base) propane-2-en-1-one (413 mg, yield: 99.27%) was a yellow solid.
According to the analysis of related databases, 1402838-08-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem