Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., name: 2-Ethyl-1H-imidazole
The after-dihydro-furo indanol (6,1.76g, 10mmol) was dissolved in toluene (in 80 ml of), was added thionyl chloride (4.91ml, 30.4mmol), for 2 hours at 55 was heated with stirring, and concentrated under reduced pressure , was prepared chloro; which was dissolved in toluene or acetonitrile solvent (in 80 ml of), was added 2-ethyl imidazole (2.88g, 30mmol), the reaction was stirred at reflux for 24-48 hours. after the solvent was concentrated under reduced pressure, purified by silica gel column chromatography chromatography (100-200 mesh), petroleum ether – ethyl acetate (3:1 ? 1:1) as eluent, to give preparation of 1- (furo-dihydro-inden-alkoxy) -2-ethyl imidazole (8c, 1.52 g), yield 60%;
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Yunnan University; Yang Xiaodong; Zhang Hongbin; Chen Wen; Wang Xuequan; Yang Lijuan; Li Liang; (38 pag.)CN102766135; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem