Application of 89830-98-8, These common heterocyclic compound, 89830-98-8, name is 5-Cyclopropyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
NaH (60 mass%) in minera oi (148 mg, 3.6989 mmo) is added to a soution of 4-cycopropy-1H-imidazoe (200 mg, 1.8495 mmo) in DMF (2 mL) at 0 C under anitrogen atmosphere. The mixture is stirred at 0 C for 15 minutes. 1 ,2-Dibromoethane(0.504 mL 5.5484 mmo) is added at 0 C and the mixture is stirred at room temperaturefor 4 hours under a nitrogen atmosphere. The reaction is quenched by addition of water.The mixture is extracted with EtOAc (3x). The organic phase is washed with saturatedNaC (3x), dried over Na2SO4, fitered, and concentrated to dryness. The residue ispurified by siica ge flash chromatography with 3% MeOH in DCM to give the titecompound as a mixture of 1-(2-bromoethy)-4-cycopropy-imidazoe and 1-(2- bromoethy)-5-cycopropy-imidazoe regioisomers (120 mg, 28.7%) as a cooress oi. ES/IVIS (m/z): 215 (M+1).
The synthetic route of 89830-98-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; LIU, Lian Zhu; WANG, Xiaoqing; WILEY, Michael Robert; (34 pag.)WO2019/50794; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem