Synthetic Route of 870837-18-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Method B, Step 3: (7aS,12a1R)-10-fluoro-3-(3-methoxy-4-(4-methyl-1 H- imidazol-1 -yl)styryl)-6,7,7a,8-tetrahydro-5H-indeno[1 ,2- b][1,2,4]oxadiazolo[4,5-a]pyridine (B3, R9 = 4-(4-Methylimidazol-1-yl), R10 = 3- MeO-Phenyl) B2 (0.24g, 0.63mmole) was dissolved in THF and the reaction was cooled to -78C. n-Butyllithium (2.5ml in Hexane, 0.28ml) was added and the reaction was stirred at -78C for 30 minutes. 3-methoxy-4-(4-methyl-1 H-imidazol-1- yl)benzaldehyde (0.136g, 0.63mmole) in 10 ml THF (Pre-cooled to -78C) was added. The reaction was stirred at -78C for 1 hour, then at room temperature for one hour. THF was removed and the residue was partitioned between 100ml EtOAc and 100ml water. The organic layer was washed with water (2x100ml), dried with Na2SO4 and concentrated. The residue was purified by column (EtOAc/hexane from 25/75 to 100/0 in 45 minutes, 12Og silica). Yield: 0.19g, 68%. 1H NMR (CDCI3400 MHz): 7.73 (s, 1 H), 7.50 (dd, J = 8.1 , 5.12 Hz, 1 H), 7.43 (d, J = 16.8 Hz, 1 H), 7.27 (m, 1 H), 7.18 (d, J = 8.1 Hz, 1 H), 7.13 (s, 1 H), 7.00 (m, 3H), 6.52 (d, J =16.1 Hz, 1 H), 3.90 (s, 3H), 3.71 (m, 1 H), 3.30 (dd, J = 16.1 and 5.9 Hz, 1 H), 2.91 (m, 1 H), 2.64 (m, 1 H), 2.38 (d, J = 16.1 Hz, 1 H), 2.30 (s, 3H), 2.06, (m, 1 H), 1.51 (m, 2H), 1.10 (m, 1 H). MS (M+1 ): 445.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SCHERING CORPORATION; WO2008/153792; (2008); A2;,
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