New downstream synthetic route of 1-Methyl-1H-imidazole

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 616-47-7.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 616-47-7, name is 1-Methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H6N2

General procedure: N-methyl imidazole (17.53 ml, 0.22 mol) and 1,4-butane sultone (20.5 ml, 0.20mol) were dissolved in toluene (60 ml) and stirred for 8h at 60ºC under nitrogen atmosphere. The white zwitter ion solid so formed was filtered and washed repeatedly with diethyl ether (3 × 40 ml) to remove non-ionic residues.The resulting solid (MIM-BS) was dried in vacuum for 8h. The MIM-BS (10.0 gm,0.0463 mol) was dissolved in water (2 ml) with constant stirring.Methanesulfonic acid (3 ml, 0.0463 mol) was taken in water (1 ml) and added to the reaction contents dropwise. The mixture was stirred for 6h at 85ºC. After completion of the reaction, water was removed and contents were dried for 24h under reduced pressure. The resulting colorless viscous liquid was stored in dry box for further use.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 616-47-7.

Reference:
Article; Garg, Bhaskar; Ling, Yong-Chien; Tetrahedron Letters; vol. 53; 42; (2012); p. 5674 – 5677;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem