Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 150058-27-8, name is Methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
To a solution of methyl 2-ethoxy-lH-benzo[d]imidazole-7-carboxylate (55.5 mg, 0.252 mmol) in DMF (2 mL) was added sodium hydride (60percent) (16.78 mg, 0.420 mmol) at RT. The reaction mixture was stirred for 10 min at RT before methyl 4″-(bromomethyl)- [l,l’:3′, l”-terphenyl]-4′-carboxylate (Intermediate 400b, 80 mg, 0.210 mmol) was added in its own solution of DMF (1 niL). After 50 min of stirring at RT the reaction mixture was diluted with EtOAc and washed with 10percent LiCl (aq). The organic phase was dried over MgS04, filtered over celite, and concentrated. The residue was dissolved DMF and purified by ISCO (0-100percent EtOAc/Hexanes) to afford the title compound (Intermediate 314a, 48 mg, 0.069 mmol, 33.0 percent yield). LC-MS Retention time (Method A2) = 1.20 min. Found m/z: 520.1 (M+H)+. H NMR (400MHz, CDC13) delta 7.89 (d, 7=8.1 Hz, 1H), 7.66 – 7.57 (m, 4H), 7.55 – 7.49 (m, 2H), 7.49 – 7.31 (m, 4H), 7.22 (d, 7=8.4 Hz, 2H), 7.01 (d, 7=8.1 Hz, 2H), 5.66 (s, 2H), 4.68 (q, 7=7.1 Hz, 2H), 3.78 (s, 3H), 3.57 (s, 3H), 1.54 – 1.48 (m, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
Imidazole – Wikipedia,
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