Some common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H6N2O
A mixture of i-methyMH-imidazole-4-carbaldehyde (0.50 g), N- bromosuccinimide (0.89 g) and chloroform (7.0 ml_) was heated at reflux for 2 hours. The mixture was cooled to O0C, diluted with saturated aqueous sodium carbonate solution (10 ml_) and extracted with dichloromethane. The combined organic extract was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with a mixture of ethyl acetate and dichloromethane (0:1 to 7:10 by volume) to afford the title compound as a white solid (0.37 g).1H NMR (CDCl3): delta 3.70 (s, 3H), 7.66 (s, 1 H), 9.89 (s, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17289-26-8, its application will become more common.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2009/77728; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem