Application of 152628-02-9,Some common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 2-n-propyl-4-methyl-6-( -methylbenzimidazol-2′-yl) benzimidazole 100 g in 1000ml of acetone and of potassium hydroxide 22.0 g with stirring at 20-25C. Then of 4-bromomethyl-2′-cyanobiphenyl 92g is added at 20-25 C. Monitor the reaction on thin layer chromatography, after the reaction is completed, cooled to 0 to 5.0 C. and stirred for another hour at this temperature. The material is filtered, washed with chilled acetone, then wash with water, and then dried in a air drying cupboard at 80 C. Yield: 141.50 g (87.73% of theory); melting point: 196 C.-197 C; HPLC: 99.50%. N-3 isomer: 0.16%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, its application will become more common.
Reference:
Patent; INOGENT LABORATORIES PRIVATE LIMITED; RAY, Purna, Chandra; NIGAM, Satish; PANDEY, Anand, Kumar; PATIL, Premchand; REDDY, Jagan, Mohan; ORUGANTI, Nagaraju; WO2011/77444; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem